Ipratropium Bromide

描述

pratropium bromide‌ is a muscarinic antagonist (pKₐ 8.8) that selectively blocks M3/M1 receptors, reducing bronchoconstriction via parasympathetic inhibition, primarily used in COPD/asthma.
This quaternary ammonium salt (m.p. 220–221°C) is delivered via aerosol (e.g., Atrovent®), with minimal systemic absorption due to its polar structure.